Peyronie’s disease refers to an abnormal curvature of the penis caused by calcifications or plaques that develop spontaneously. It is now called Chronic Inflammation of the Tunica Albuginea (CITA) which is the thick covering beneath the penile skin that allows the penis to maintain an erection. It is a connective tissue disorder but the true cause of this disease is unknown, although many believe it may be related to trauma experienced through intercourse which may heal poorly forming the characteristic scar. There is a strong association between Peyronie’s disease and Dupuytren’s contractures and many who have one usually have the other. About 10% of patients improve on their own, while the 50% progress and the rest stay stable over time. Treatment can be medical through injections directly into the plaque or through a variety of medications by mouth. Devices can also help minimize the curvature to maintain sexual function. Surgery can be corrective, but it is usually tried after other treatments have failed.